ToolTrust
A2/100
Smithery

nullary-drug-discovery

mcpsmithery

@Smithery

Nullary is an MCP server providing structured, citable access to negative results in drug discovery. Every record carries full provenance (DOI, PMID, source URL, license). Covers 7 modalities: small molecules (84.5M records), CRISPR (37.6M), clinical trials (104K terminated), peptides, antibodies, PROTACs, and oligonucleotides. Sources include ChEMBL, PubChem BioAssay, DepMap, BioGRID ORCS, GenomeCRISPR, ClinicalTrials.gov, EudraCT, Drugs@FDA, Thera-SAbDab, SAbDab, FLAb, PROTAC-DB, THPdb, AOBase, Retraction Watch, and 10 others. Fully cited.

By Smithery | 92 findings | Scanned 7/3/2026 | tooltrust-scanner/v0.3.19

28 Low64 Info

Risk Summary

Safe With Normal Controls

Dep Visibility is the main signal, but overall risk remains within an acceptable range.

Potential impact: This finding indicates the tool should be reviewed before it is trusted.

Recommended action: No high-risk findings were detected in this scan, but you should still apply least-privilege defaults and rescan after changes.

Suggested policy: keep this tool behind manual approval, do not allow unattended runs, and re-scan after narrowing risky permissions.

Security Findings (92)

  • LowAS-011

    ℹ️Missing Rate-Limit / Timeout ×28

    tool performs network or execution operations but declares no rate-limit, timeout, or retry configuration

    search_inactive_compoundssearch_failed_selectivitysearch_admet_failuressearch_failed_guidessearch_failed_essentiality_screenssearch_ancestry_specific_failuressearch_developability_failuressearch_failed_clinical_antibodiessearch_failed_peptide_therapeuticssearch_peptide_stability_issuessearch_failed_protacssearch_protac_e3_issuessearch_failed_oligonucleotidessearch_oligo_delivery_failuressearch_failed_vaccinessearch_vaccine_immunogenicity_failuressearch_failed_adcssearch_adc_linker_failuressearch_failed_bispecificssearch_bispecific_format_failuressearch_admet_failures_all_modalitiessearch_drug_drug_interaction_failuressearch_mechanism_failuressearch_failed_replicationssearch_safety_failuressearch_target_historysearch_indication_historysearch_pathogen_history

    Fix: Declare explicit rate-limit, timeout, and retry configuration for all network and execution tools. Implement exponential back-off and surface resource state to the calling agent.

  • InfoAS-002

    ⚠️Excessive Permissions ×29

    declared capabilities: network access

    search_inactive_compoundssearch_failed_selectivitysearch_admet_failuressearch_failed_guidessearch_failed_essentiality_screenssearch_ancestry_specific_failuressearch_developability_failuressearch_failed_clinical_antibodiessearch_failed_peptide_therapeuticssearch_peptide_stability_issuessearch_failed_protacssearch_protac_e3_issuessearch_failed_oligonucleotidessearch_oligo_delivery_failuressearch_failed_vaccinessearch_vaccine_immunogenicity_failuressearch_failed_adcssearch_adc_linker_failuressearch_failed_bispecificssearch_bispecific_format_failuressearch_admet_failures_all_modalitiessearch_drug_drug_interaction_failuressearch_mechanism_failuressearch_failed_replicationssearch_safety_failuressearch_target_historysearch_indication_history

    declared capabilities: network access, filesystem access

    search_pathogen_history

    declared capabilities: filesystem access

    get_compound

    Fix: Tool requests broad permissions (exec/fs/network). Validate input parameters using Enums where possible, and restrict file system operations to explicit allowed directories.

  • InfoAS-014

    ℹ️Dependency Inventory Unavailable ×35

    Tool did not expose metadata.dependencies or repo_url, so supply-chain coverage is limited.

    search_inactive_compoundssearch_failed_selectivitysearch_admet_failuressearch_failed_guidessearch_failed_essentiality_screenssearch_ancestry_specific_failuressearch_developability_failuressearch_failed_clinical_antibodiessearch_failed_peptide_therapeuticssearch_peptide_stability_issuessearch_failed_protacssearch_protac_e3_issuessearch_failed_oligonucleotidessearch_oligo_delivery_failuressearch_failed_vaccinessearch_vaccine_immunogenicity_failuressearch_failed_adcssearch_adc_linker_failuressearch_failed_bispecificssearch_bispecific_format_failuressearch_admet_failures_all_modalitiessearch_drug_drug_interaction_failuressearch_mechanism_failuressearch_failed_replicationssearch_safety_failuressearch_target_historysearch_indication_historysearch_pathogen_historyget_compoundget_finding_provenanceget_target_landscapelist_top_targetslist_modelsget_model_cardget_coverage

    Fix: Review and remediate the identified issue.

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$ curl -sfL https://raw.githubusercontent.com/AgentSafe-AI/tooltrust-scanner/main/install.sh | bash
$ tooltrust-scanner scan --server "npx -y nullary-drug-discovery"

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